Kirkwood, including in patients with more than four prior therapies. Responses were also seen regardless of the number of prior therapies, said Dr.
Similar responses were observed across baseline characteristics, including ECOG performance status 0 or 1 and BRAF V600E/K–mutated disease vs wild-type status. Conversely, vidutolimod monotherapy had a median duration of only 5.6 months. The combination of vidutolimod and pembrolizumab also resulted in durable responses, with a median duration of response of 25.2 months.
In the 40 patients who received vidutolimod monotherapy, the best overall response rate per RECIST criteria was 20%.
#Typestatus plus plus#
In 98 patients receiving vidutolimod plus pembrolizumab, the best overall response rate per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 was 23.5%. Kirkwood reported, antitumor activity was observed with vidutolimod in combination and as monotherapy. The demographics and baseline characteristics were similar across groups.Īs Dr. Kirkwood and colleagues enrolled a total of 159 patients in part 1 and 40 patients in part 2 of the trial. The objective of this two-part, open-label, multicenter phase Ib study was to assess the safety and antitumor activity of vidutolimod alone and in combination with pembrolizumab in patients with advanced melanoma and prior disease progression on anti–PD-1 therapy.ĭr. Vidutolimod is a first-in-class immunostimulatory noninfectious viral particle that contains a CpG-A toll-like receptor 9 agonist and is delivered as a biologic virus-like particle. “Vidutolimod also demonstrated single-agent activity, but the substantially longer duration of response with pembrolizumab provides strong rationale for further development of vidutolimod in combination with PD-1 blockade.”
Kirkwood, Professor of Medicine, Dermatology, and Clinical and Translational Science at the University of Pittsburgh School of Medicine. “Tumor regression was seen both in injected and in noninjected lesions, supporting a systemic immune effect of vidutolimod,” said lead study author Dr. Responses were also durable, with a median duration of response of more than 2 years in responders. Authors of the study reported an overall response rate of 23.5% 7.1% of patients achieved a complete response. Results from a phase Ib study showed that treatment with vidutolimod plus pembrolizumab demonstrated promising clinical antitumor activity in patients with PD-1 blockade–refractory melanoma. Kirkwood, MD, and colleagues at the Society for Immunotherapy of Cancer (SITC) 2021 Annual Meeting ( Abstract 950). The addition of vidutolimod to pembrolizumab could help overcome resistance to immune checkpoint inhibition in patients with metastatic or unresectable cutaneous melanoma, according to data presented by John M.
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